The Louisville Cardinals hit the road in ACC competition to face the Clemson Tigers in an NCAA college football game set for Saturday.

Start Time: 8PM ET

Location: Clemson

TV: ABC

College Football Point Spread Odds: Clemson -2

Money Line: Clemson -120 odds and Louisville +110 odds

Over Under Total:

Notes: They met in 2015 with Clemson earning the 20-17 home victory as a -5 point favorite.

Louisville moves to 4-0 on the campaign with the 59-28 road victory to the Marshall Thundering Herd as a -31 point betting favorite. The total went over 69 points. Louisville was up 52-7 after three quarters. They moved the ball for 690 yards and averaged 6.7 yards per carry on the ground on 41 rushing attempts. Lamar Jackson hit on 24 of 44 passes for 417 yards with five touchdowns and a pick. They allowed Marshall 220 yards of offense along with 2 of 15 on third down with only 59 yards passing.

Clemson is 4-0 on the season following the 26-7 road victory at the Georgia Tech Yellow Jackets as a -10 ½ point favorite. The total went under 58 points. The Tigers took a 23-0 lead into the half. It was a very good defensive effort as the Yellow Jackets could gain only 124 offensive yards with 29 through the air and of 12 conversions on third down. Tigers quarterback Deshaun Watson hit on 32 of 48 passes for 304 yards with two touchdowns and a pick.