The Louisville Cardinals will hit the highway in week six to face the Tempe Owls in an NCAA college football game scheduled for Saturday afternoon.

Kick off time from Temple is slated for 12PM Eastern Time with national television coverage provided by ESPN Game Plan.

The college football odds from this game have the road side Louisville Cardinals favored by -31 ½ points with an over under line of 58 points.

Louisville is a perfect 4-0 on the season after a 72-0 home victory in week four against the Florida International Golden Panthers as a -41 point betting favorite. The game total finished at over 55 ½ points. The Cardinals went up 38-0 at the half.