Dr. Mario video review. Classic Game Room reviews DR. MARIO for Nintendo Game Boy from 1990, a Nintendo produced puzzle game for Nintendo Gameboy It's Tetris meets the back-alley drug dealer, it's Dr. Mario, an addictive puzzle game featuring NIntendo's Mario in a lab coat and slippers! Drop pills on viruses to kill them off when you stack four of the same colored pill segments on top of them. Dr. Mario starts off easy and gets insanely difficult as the screen fills with the virus that spreads to kill off your Game Boy. This CGR Dr. Mario video review has gameplay from Dr. Mario on GameBoy showing Dr. Mario gaming in action