Main Aurr Mrs. Khanna revolves around the story of Samir Khanna (Salman Khan) and Raina Khanna (Kareena Kapoor) who have a fairytale marriage. Samir gets his dream job and they have a great life until one wrong decision leads them to part their ways.

Kareena Kapoor falls in love with Sohail Khan and eventually breaks up with Salman Khan.