This is one of Buxtehude's chorales that are not in monodic style.
Unlike BuxWV 220 (on the same chorale tune), BuxWV 221 is full of grandeur, which led us us to choose "Organo Pleno" as the proper registration, according to our musical conception. The pedal must be dealt with as a highly assertive voice, following the "Werkprinzip" mood, since it makes several sudden entrances of great strength.
Another possibility is to see this marvelous piece of music as an "allemande", rethinking it as a whole and changing the registration to something lighter... much lighter.