Dr. Tess Martin (Anne Heche), a specialist from the Global Health Organization, is called in to investigate a mysterious illness that is filling up Spokane's hospitals. She is contacted by Jack (James Tupper), who inform her that the disease is caused by a deadly substance called "E901" being added to jet fuel to "weed out the old and the sick". As the situation escalates, 70% of the population is infected, and Spokane is placed under quarantine, trapping Martin inside. Together they battle operatives of the Keller corporation as they attempt to escape the city to find a cure.