Jesse James Meets Frankenstein's Daughter is a 1966 American Western-horror film directed by William Beaudine. This film is often noted for its low-budget production and unique genre-mixing premise, combining elements of a Western with those of classic horror.
The plot follows the infamous outlaw Jesse James as he encounters Dr. Maria Frankenstein, the granddaughter of the famous Dr. Frankenstein, who is continuing her family's experiments in the American West. Maria Frankenstein, along with her brother Rudolph, is attempting to create a race of superhumans by transplanting brains into different bodies. Jesse ends up clashing with the Frankenstein siblings when one of his wounded companions becomes the subject of their latest experiment.
This film is part of a pair of releases by Beaudine, the other being "Billy the Kid Versus Dracula," which shares a similar concept of mixing Western figures with classic monster themes. The two films were originally released as a double feature. "Jesse James Meets Frankenstein's Daughter" is often remembered for its campy style and has gained a cult following over the years.