First broadcast 21st March 1994.

Sherlock Holmes and his brother Mycroft investigate the murder of an amanuensis who clutches a pince-nez and whose last words were, "The professor - it was she."

Jeremy Brett ... Sherlock Holmes
Charles Gray ... Mycroft Holmes
Rosalie Williams ... Mrs Hudson
Frank Finlay ... Professor Coram / Sergius
Nigel Planer ... Inspector Hopkins
Anna Carteret ... Anna
Natalie Morse ... Susan Tarlton
Patricia Kerrigan ... Abigail Crosby
Christopher Guard ... Willoughby Smith
Kathleen Byron ... Mrs Marker
Roger Ringrose ... Alexis
Daniel Finlay ... Vladimir
Harry Kirkham ... Mortimer