Cologne, a 2,000-year-old city spanning the Rhine River in western Germany, is the region’s cultural hub. A landmark of High Gothic architecture set amid reconstructed old town, the twin-spired Cologne Cathedral is also known for its gilded medieval reliquary and sweeping river views. The adjacent Museum Ludwig showcases 20th-century art, including many masterpieces by Picasso, and the Romano-Germanic Museum houses Roman antiquities.