In 1868, at the tail end of the Industrial Revolution, with the Assassin Brotherhood all but eradicated, twins Jacob (Paul Amos) and Evie Frye (Jennifer Hale) leave Crawley for London and arrive to find a city controlled by the Templars, with both the Church and the Monarchy losing their power. Raised as Assassins to follow the Creed, Jacob and Evie aim to take back the city from Templar control by infiltrating and uniting London's criminal underworld, aided by notable figures of the era such as novelist Charles Dickens and biologist Charles Darwin.