The renowned actor and director George Clooney did not receive his most coveted, best piece of advice from a sage fellow thespian—in fact, the guidance didn't have to do with acting at all. "Never mix grain and grape," he says of the best advice he's ever received. (His aunt Rosemary told him this when he was seven years old.) "No wine and, like, tequila. We learn early in Kentucky—a lot of things." It may not have been the nugget of information that catapulted him into stardom—where he's remained since the mid 1990s—but it is in line with the cheerful, laid-back demeanor for which Clooney is so well-known. In this episode of Screen Tests with Lynn Hirschberg, Clooney describes how this outlook on life was tested: both during the pandemic while cleaning up after his kids, and on set filming his directorial debut, The Midnight Sky, amid sub-zero temperatures.