Unable to play video. In 2016, when the first Deadpool dominated the box office, fans fell in love with the title character's eccentric roommate, Blind Al. Played by Leslie Uggams, Blind Al plays the straight mind to Deadpool's wacky antics, making for an interesting, albeit hilarious relationship. While Blind Al is usually a serious character, she's placed within a laugh-out-loud comedy with an actor like Ryan Reynolds, whose been known to improvise and have his co-stars rolling between takes.