Dishonored 2 Keyboard + Mouse not working
Fix Update - http://dishonored2fix.tumblr.com

To resolve the problems in the game you need to download and install this patch fix.
Additionally, you can close all other background processes to free up system resources. The good news is that most of the people experiencing these severe "falling down" only in the throne room, and as soon as the "slip" this location, you will be able to "breathe freely". It is not present and the wrong, but the best solution available today.