MINNEAPOLIS -- Ettore Messina had a simple goal when he took over the San Antonio Spurs for two games while coach Gregg Popovich stayed home to tend to a family matter.

"The machine is a well-oiled machine," Messina said. "It goes on. You try to sit at the wheel and steer and try not to mess it up. Keep it straight."

After veering off course in Indiana, Messina steered the Spurs back on to the track in an overwhelming performance against Minnesota.

LaMarcus Aldridge had 29 points and seven rebounds to help the Spurs bounce back from a rare loss with a 116-91 victory over the Timberwolves on Tuesday night.

Kawhi Leonard scored 15 points and the Spurs (54-10) led by as many as 26 points in a game they played without Tim Duncan, Tony Parker, Manu Ginobili and Popovich. David West scored 18 points as the Spurs shot 55.3 percent and only turned the ball over nine times.

"I thought guys came back understanding we have to be better on both ends of the floor," Aldridge said.

Andrew Wiggins had 23 points and eight rebounds for the Timberwolves. Karl-Anthony Towns had 19 points and nine boards, and Zach LaVine scored 15 points.

The Wolves have been playing for some time without Kevin Garnett (leg), Nikola Pekovic (foot) and Nemanja Bjelica (foot), and ran out of gas in their fourth game in five nights.

"They need to remember these losses though," interim coach Sam Mitchell said. "If you're ever going to get better, if you're ever going to win, you have to remember the times where you got your butt kicked."

The Spurs haven't dealt with much losing this season, and they responded to their 10th defeat of the season with a workman-like dismantling of the Timberwolves. Even with their three mainstays out of the lineup and their peerless coach at home tending to a family issue, they didn't miss a beat.

The Spurs shot a season-low 35 percent overall and 14 percent from 3-point range against Indiana on Monday night. They were much better against Minnesota's young and porous defense. Aldridge got whatever he wanted, peppering the Wolves with midrange jumpers and throwing down an emphatic dunk on Towns to get the Spurs going in the second quarter.

San Antonio closed the half with a 9-0 run, then just leaned on the young Wolves in the third to break it open.

The Spurs turned the ball over just three times in the first three quarters and now head home for five straight games at AT&T Center, where they are 30-0 this season.