A hospital supported by medical charity Medecins Sans Frontieres in the Idlib province of northern Syria was "deliberately" hit by air strikes on Monday and eight people are missing, MSF said in a statement.
"This is a deliberate attack against a health establishment," said Massimiliano Rebaudengo, MSF head of mission.
"The destruction of this hospital deprives about 40,000 people of healthcare in this conflict zone."
MSF said the hospital was destroyed after being hit by four missiles following two attacks within a few minutes interval.
The hospital, which has 54 staff and holds 30 beds, is financed by the medical charity.