UFC Fight Night: Dillashaw vs. Cruz (also known as UFC Fight Night 81) was a mixed martial arts event held on January 17, 2016 at the TD Garden in Boston, Massachusetts.

A UFC Bantamweight Championship bout between then current champion T.J. Dillashaw and former WEC and UFC Bantamweight champion Dominick Cruz headlined this event.

Beneil Dariush was expected to face Mairbek Taisumov at this event. However, on December 3, Dariush was forced to pull out of the bout due to injury. He was replaced by Chris Wade. In turn, Taisumov was pulled from the fight during the week leading to the event due to alleged visa issues and was replaced by promotional newcomer Mehdi Baghdad.