Bo Emperor Bill has a problem. After winning the Great Galaxy Bodybuilding Contest ten times in a row, he has found that he has virtually exhausted his protein supplies. Not one to sit around complaining, he decides to invade nearby galaxies and set up factories, harvesting the protein for his own use. However, the heaven realm does not like the look of all this, and sends two warriors - Idaten and Benten to thwart his plans.

Playing similarly to most shoot 'em ups, Cho Aniki features the usual power-up pods that increase your damage, super weapons that devastate and R-Type style orbs in the form of muscle-bound brothers Adon and Samson. Levels are split into various stages with lots of sub-bosses thrown in for good measure