Halo: The Master Chief Collection contains every Campaign level from the included games playable in their original engines. All missions are unlocked from the start.The 15 Halo 2 Campaign missions were remastered for Halo 2: Anniversary. Each game runs at 1080p and 60 frames per second,[4] with the exception of the Halo 2: Anniversary Campaign, which runs at 1328x1080 as a result of running two rendering engines at the same time.

The Collection will support both split-screen and online cooperative play. Halo: Combat Evolved Anniversary and Halo 2: Anniversary will support a maximum of two players while Halo 3 and Halo 4 will support a maximum of two players locally and four players online.

The Campaign system features Mission Playlists, which contain mixes of missions within the same Campaign or mixes of missions spanning multiple Campaigns.