The Cleveland Indians will open up a weekend four game series against the Boston Red Sox in a Major League Baseball game betting pick selection on Thursday night.

First pitch from Boston is set for 7PM Eastern Time with national television coverage provided by the MLB Network.

The odds from Game 1 of this contest have the home side Boston Red Sox favored by -155 odds with the take back on the road underdog Cleveland Indians at +135 odds. The run total is lined at 8 ½ runs.