Tottenham ended their 23-year wait for a victory at Old Trafford as they held on to take the points against Manchester United in a pulsating encounter.
Spurs looked to be in total control after first-half goals from Jan Vertonghen and Gareth Bale gave them a comfortable advantage at the break.
But United, who were awful in the first period, hit back through Nani before Clint Dempsey restored Tottenham's two-goal advantage.
Shinji Kagawa immediately struck again for United as they poured forward in a bid to maintain their long unbeaten run against Spurs.
United pressed hard with substitute Wayne Rooney and Michael Carrick hitting the woodwork and they saw several appeals for a penalty waved away by referee Chris Foy.
It was a victory which delighted the large contingent of Tottenham fans who last saw their side win at Old Trafford in 1989 when Match of the Day presenter Gary Lineker scored the winner for Terry Venables' side.
For United, it was their second defeat in six Premier League games, and manager Sir Alex Ferguson could have more defensive injury problems after Jonny Evans finished the game in some discomfort.
Watching England manager Roy Hodgson will not have seen anything to change his mind about not picking United defender Rio Ferdinand for "footballing reasons" since taking over from Fabio Capello.
Ferdinand struggled against Tottenham's dangerous forward line and he did virtually nothing to boost his chances of a call-up for the World Cup qualifiers against San Marino and Poland in a fortnight.
Tottenham stunned the vast majority of the 75,566 crowd inside two minutes when they took the lead after a neat one-two between Vertonghen and Bale.
United backed off and Vertonghen burst into the penalty area and evaded a half-hearted Ferdinand challenge before striking a low shot which deflected into the net off Evans.
It was a lead Spurs deserved as they took the game to United who barely had a touch in the opening 10 minutes.
Tottenham looked assured and tota