The Indianapolis Colts will hit the road in AFC South divisional play when they face the Jacksonville Jaguars in an NFL pro football game on Sunday afternoon.

Kick off time from Jacksonville is scheduled for 1PM Eastern Time with national television coverage provided by CBS.

The betting odds from this week four NFL game have the road team Indianapolis Colts favored by -7 ½ points with an over under line set at 42 ½ points.

Indianapolis improves to 2-1 on the season after a 27-7 road win last week to the San Francisco 49ers as a +10 ½ point betting odds underdog. The total came in at under 45 ½ points. After going up 10-7 at the half the Colts outscored San Francisco 17-0 in the second half.