The Detroit Lions will conclude their preseason scheduled as they travel to play the Buffalo Bills in an NFL pro football exhibition game on Thursday night.

Kick off time from Buffalo is set for 7PM Eastern Time with live television coverage available only in the Detroit and Buffalo markets.

The NFL odds from this preseason week four game have the road side Detroit Lions favored by -4 ½ points with an over under line set at 40 points. A money line play on the Detroit Lions will return -220 odds with the take back on the Buffalo Bills at +180 odds.